The Power of Peptides for the Skin.


Peptides for the skin? Do you need them?

Sometimes, there are skincare ingredients like peptides for the skin that may spark your interest. But, perhaps they seem a little mysterious or, too good to be true.

They sound like something your skin needs, and the beauty consultant thought you did too. But, they couldn’t explain why? You want to trust them; after all, it’s a well-known brand. Why not? Right? Well, sometimes. 

With so many ingredients popping up every second minute, you’d be wise to understand why you need them before spending any money.

You’ve never heard of peptides for the skin?

If you’re new to the power of peptides for your skin, then it might be time to listen up or should I say, read on.

Peptides take your skincare routine beyond the basics, or if you’re already on a fairly comprehensive beauty regimen, then peptides up the ante.

There has been much said about the power of peptides for the skin. You deserve to know what you’re getting before you spend your money.

It’s fair to wonder:

What are they? And, why am I using them? Is it going to do anything? Or, should I repurchase another bottle of those peptide watcha-ma-call-its?


Let’s start with a little science.

Peptides are essential for the proper function of every cell in your body, including the cells of your skin. And, just as protein is vital for a healthy body, it’s well established we also need peptides for the skin.

A peptide is a short chain of amino acids, whereas a protein is a long chain. These peptides comprise amino acids which become mini-proteins, the building blocks for larger proteins.

When specific amino acids are combined, they form particular peptides, of which there can be many variations.

When it comes to your skin hopefully, your skincare professional will recommend a peptide designed to solve your specific skin dilemma.

Still a little confused?

Okay then, let’s put it another way. Your collagen gives your skin its strength, and when in decline, your skin will begin to sag, wrinkles will form, and the texture of your skin becomes uneven. Collagen is a protein made up of long-chain amino acids and requires peptides to build and support it.

The proteins formed by peptides keep your skin intact. Peptides reduce the degradation of collagen caused by a lifetime of exposure to the sun and the environment. 

Generally, peptides for the skin can be classified into the following activities…



Peptides that send messages between cells to orchestrate positive activities such as the formation of collagen and elastin. Great if you want to reduce visible signs of ageing. 


A peptide with the ability to inhibit destructive enzymes which, if left unchecked, destroys collagen and elastin. Very useful if you want to prevent premature ageing. 


Also known as neuropeptides that are active on nerves. For example, peptides that inhibit the release of chemicals from nerves to stimulate muscle fibres. These have a botulinum-like effect of reducing muscle tone. But, let’s be honest. They won’t replace a relaxing muscle injection. However, if used correctly these neuropeptides will relax the underlying muscle just enough to soften the look of your frown lines or, extend the time between visits to your cosmetic doctor (if that’s what you’re into). 

Mover and Shakers.

These are carrier peptides that convey essential minerals like copper into the skin. (In the skin, copper is involved in the synthesis and stabilisation of extracellular matrix skin proteins and angiogenesis). Or, in other words, copper is essential for skin health, so this is a good thing as long as you find a quality formula. 


Intelligent peptides altering pigmentation by inhibiting the production of melanin that can lead to uneven and blotchy pigmentation. You’ll find the best results will be achieved when you combine these peptides with other proven ingredients that inhibit pigment production and transfer such a Niacinamide, Alpha Arbutin and Sepi White to name but a few.

Free radical scavengers.

These are essential peptides with antioxidant activity to disable the damaging effect of too many free radicals in the skin, which are primarily caused by unpaired oxygen molecules causing chaos and ultimately dysfunction in the skin. 

So, which one is for you?

When looking for a peptide, it helps to be clear on what you want to change or improve about your skin. And, if you find the right formula, then you’re skin will be all the better for it.

The Queen of Peptides.

Matrxyl 3000!! A combination of two peptides.

Matrixyl 3000, is the trademarked name given by to this peptide formula by Sederma and comprises Palmitoyl Tetrapeptide-7 and Palmitoyl-Oligopeptide.

Sederma has claimed that Matrxyl 3000 is as good as topically applied Vitamin C.

Better than topically applied vitamin C?

Now, let me say this. I’m a big, huge fan of vitamin C topically applied to the skin. So, if the clinical trials stack up then the two peptides in Matrxyl 3000 could outperform the naturally occurring version of vitamin C known as L-Ascorbic Acid. For me, that’s a winner!!

But, hold on a minute.

It’s all well and good to make big claims and if there’s evidence to support the claim. Great!! Even so, I’m going to hedge my bets. I’ll always choose to combine my peptides with a nice dose of topically applied vitamin C.

You’ll find many good skincare brands feel the same way and combine vitamin C with peptides. 

Combining these peptides with a well-formulated and stable vitamin C, such as Ascorbyl Tetraisopalmitate will protect the skin’s barrier function. A significant factor as, (along with sun damage) in the skin losing its integrity and showing visible signs of ageing.

Peptides versus Vitamin A?

Another significant and bold statement is the comparison to topical Vitamin A!! Up until now, Vitamin A is the only molecule proven to give broad-scale skin rejuvenation, including DNA repair.

Despite all this, is it worth taking heed and introducing peptides into your routine?

Well, yes. But, even though Matryxl 3000 may provide similar results to vitamin A, there’s no evidence to suggest these peptides can repair the DNA of the cell. Nor can they bring about therapeutic changes to the skin at a cellular level.

Matryxl 3000 is a great ingredient, but not quite a match for the stellar credentials of Retinoic Acid (vitamin A), and it’s derivatives. 

Even so, clinical trials demonstrate the potential synergy between vitamin A and Matrixyl 3000.

So, if the reduction of visible signs of ageing and future-proofing your skin is your priority (and it should be), then combine Matrixyl 3000 with your vitamin A & C, and you’ll have an excellent anti-ageing regimen not to be challenged.

Now that I’ve got you interested…

A brief list of the most popular peptides available for Anti-Ageing

Matrixyl™ (Palmitoyl Pentapeptide-4) – Helps stimulate collagen synthesis and elastin. Comparable to retinol without the irritation. (although, I wouldn’t be without the all-important vitamin A. 

Matrixyl™ 3000 (Palmitoyl Oligopeptide (also known as Palmitoyl Hexapeptide-12 or Palmitoyl Tridpeptide 1) and Palmitoyl Tetrapeptide-7) – This combination of peptides repairs damaged tissues and support the synthesis of collagen and elastin. This combination now widely more popular in formulations then its predecessor Matrxyl. 

Trylagen® (Tripeptide-1&10) – Tripeptide-1 is a communicating peptide known to work with copper in the skin. It will repair skin tissue that has begun to deteriorate due to age and sun exposure helping to rebuild the skin. The skin will look and feel smoother and firmer, and Tripeptide 10 inhibits the mallard reaction and reduce the effects of A.G.E.s

Matrixyl™ Synthe 6 (Palmitoyl Tripeptide-38) – Evens out skin and smoothes wrinkles by stimulating constituents of the skin matrix and dermal-epidermal junction (i.e. collagen I, II, IV, fibronectin, hyaluronic acid, and laminin 5).

The Neuro-peptides

Argireline® (Acetyl Hexapeptide-8) – A peptide alternative to botox that attenuates muscle contraction preventing the formation of fine lines and wrinkles.

Synake®  (Dipeptide diaminobutyroyl benzyl amide diacetate) – a synthetic neuropeptide mimicking the effects of Walgerin 1(a peptide found in snake venom), which acts as a muscle relaxant.  

For Hydration

Diffuporine™ (Acetyl Hexapeptide-37) – Boosts Aquaporin-3 to promote inner hydration mechanism and the exchange of water from the basal layer of the epidermis and to the stratum corneum, improving barrier function, collagen I synthesis and cellular proliferation.

For Antioxidant and environment protection.

Thermostressine™ (Acetyl Tetrapeptide-22) – Helps with cellular stress and increases HSP70 levels to prevent further environmental damage.

B-White™ (Oligopeptide-68) – Reduces MITF (microphthalmia-associated transcription factor) is intended to decrease pigmentation pathways to decrease tyrosinase activity and melanin synthesis to reduce overall skin pigmentation.

Environ Skin Care

I’ve included three products from Environ Skincare. When it comes to combining peptides with other essential nutrients, they’ve got it pretty well covered. Just click on the images, and you’ll be directed to their website for more information and where to buy. 

Environ Tri-Peptide Complex – Avance Elixir

A formula designed to give you a triple complex of peptides to support the synthesis of collagen. This lightweight serum consists of Matrixyl™ 3000 as well as two other collagen-building peptides known as Matrixyl™ Synthe 6 and Trylagen®.

This peptide formula is supported by an ingredient known as Meritage which comprises three root extracts to support the skins delicate barrier function to assist in the retention of moisture and down-regulates pigment in the skin. 

If anti-aging is your skin goal, and you want to give your skin a protective boost, then adding a serum such as Avance Elixir is a must-have in your daily beauty routine. 


Youth EssentiA Vita Peptide Eye Gel

Environ Youth EssentiA Vita-Peptide Eye Gel.

A specialised peptide treatment for your eyes. A lightweight eye gel consisting of a proprietary blend of peptides and vitamins A, C and E for skin nutrition. 

Matrixyl™ 3000 will assist in boosting collagen production, while the neuropeptides, Argireline® and Synake® provide gentle relaxation to the muscles around the eyes responsible for expression and eventually crows feet. 

This eye gel is not a replacement for muscle relaxants like Botox, although, with consistent use, it can provide soothing relief giving you a slightly more relaxed appearance around the eyes. But, it’s much more than that. Environ’s Vita-Peptide Eye Gel will give support to the delicate skin around the eye area needs through the delivery of essential nutrients.  


Environ Frown Serum

If you don’t like the idea of Botox to relax your frown, well then, Environ’s Frown Serum may be something you’d like to try. It’s a combination of the neuropeptides Argireline® and Synake®. 

The best results will be achieved when you harness the power of a home roller which creates tiny microscopically induced channels in the skin. This will allow efficient penetration of the serum, enabling the neuropeptides to relax the muscle and soften your frown.

Not a replacement for Botox, but, as I said, if you’d rather not jab your frown into submission, then this product may be a more natural alternative.  


See you next time,

The Beauty Issue